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Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish.
Shiau CE, Kaufman Z, Meireles AM, Talbot WS. Shiau CE, et al. PLoS One. 2015 Jan 23;10(1):e0117513. doi: 10.1371/journal.pone.0117513. eCollection 2015. PLoS One. 2015. PMID: 25615614 Free PMC article.
Macrophage fates were recovered in irf8 mutants after wildtype irf8 expression in neutrophil and macrophage lineages, suggesting that irf8 regulates macrophage specification and survival. ...As development progresses, tissue macrophages become apparent …
Macrophage fates were recovered in irf8 mutants after wildtype irf8 expression in neutrophil and macrophage lineages, suggesti …
Distinct regulatory networks control the development of macrophages of different origins in zebrafish.
Yu T, Guo W, Tian Y, Xu J, Chen J, Li L, Wen Z. Yu T, et al. Blood. 2017 Jan 26;129(4):509-519. doi: 10.1182/blood-2016-07-727651. Epub 2016 Dec 9. Blood. 2017. PMID: 27940477 Free article.
Macrophages are key components of the innate immune system and play pivotal roles in immune response, organ development, and tissue homeostasis. Studies in mice and zebrafish have shown that tissue-resident macrophages derived from different hematopoietic origins ma …
Macrophages are key components of the innate immune system and play pivotal roles in immune response, organ development, and tissue h …
Molecular characterization and expression analysis of eleven interferon regulatory factors in half-smooth tongue sole, Cynoglossus semilaevis.
Zhang J, Li YX, Hu YH. Zhang J, et al. Fish Shellfish Immunol. 2015 May;44(1):272-82. doi: 10.1016/j.fsi.2015.02.033. Epub 2015 Feb 28. Fish Shellfish Immunol. 2015. PMID: 25731919
In this study, we described for the first time eleven IRFs (IRF1, IRF1L, IRF2X1, IRF3, IRF4a, IRF4b, IRF5, IRF6, IRF7, IRF8, and IRF9) from half-smooth tongue sole (Cynoglossus semilaevis) and examined their tissue distributions and expression patterns under differe …
In this study, we described for the first time eleven IRFs (IRF1, IRF1L, IRF2X1, IRF3, IRF4a, IRF4b, IRF5, IRF6, IRF7, IRF8, and IRF9 …
CfIRF8-like interacts with the TBK1/IKKε family protein and regulates host antiviral innate immunity.
Li F, Liu W, Chen J, Huang B, Zheng Y, Ma J, Cai S, Li L, Liu F, Wang X, Wei L, Liu Y, Zhang M, Han Y, Zhang X, Wang X. Li F, et al. Fish Shellfish Immunol. 2023 Jan;132:108497. doi: 10.1016/j.fsi.2022.108497. Epub 2022 Dec 18. Fish Shellfish Immunol. 2023. PMID: 36539167
Phylogenetic analysis showed that CfIRF8-like clustered with mollusk IRF8 proteins and then clustered with vertebrate IRF3, IRF4, and IRF5 subfamily proteins. Quantitative real-time PCR detected CfIRF8-like mRNA in all tested scallop tissues, with the highest expres …
Phylogenetic analysis showed that CfIRF8-like clustered with mollusk IRF8 proteins and then clustered with vertebrate IRF3, IRF4, and …
Embryonic Intra-Aortic Clusters Undergo Myeloid Differentiation Mediated by Mesonephros-Derived CSF1 in Mouse.
Sasaki T, Tanaka Y, Kulkeaw K, Yumine-Takai A, Tan KS, Nishinakamura R, Ishida J, Fukamizu A, Sugiyama D. Sasaki T, et al. Stem Cell Rev Rep. 2016 Oct;12(5):530-542. doi: 10.1007/s12015-016-9668-2. Stem Cell Rev Rep. 2016. PMID: 27324145
To assess extrinsic regulation of IACs in the AGM region, we employed mouse embryos harboring a Sall1-GFP reporter gene, which allows identification of mesonephros cells based on GFP expression. Analysis of AGM region tissue sections confirmed mesonephros GFP expression. M …
To assess extrinsic regulation of IACs in the AGM region, we employed mouse embryos harboring a Sall1-GFP reporter gene, which allows identi …
Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M. Hagemeyer N, et al. EMBO J. 2016 Aug 15;35(16):1730-44. doi: 10.15252/embj.201693801. Epub 2016 Jul 13. EMBO J. 2016. PMID: 27412700 Free PMC article.
Recent studies have shown that tissue macrophages (Mphi) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize tissues before birth. ...Large-scale transcriptional profiling of Mphi precursors from the YS stage to adulthood allowe …
Recent studies have shown that tissue macrophages (Mphi) arise from embryonic progenitors of the yolk sac (YS) and fetal liver …
Composition and transcription of all interferon regulatory factors (IRFs), IRF1‒11 in a perciform fish, the mandarin fish, Siniperca chuatsi.
Laghari ZA, Li L, Chen SN, Huo HJ, Huang B, Zhou Y, Nie P. Laghari ZA, et al. Dev Comp Immunol. 2018 Apr;81:127-140. doi: 10.1016/j.dci.2017.11.015. Epub 2017 Nov 26. Dev Comp Immunol. 2018. PMID: 29180032
IRF1-11 with two IRF4, IRF4a and IRF4b have been characterised in an aquaculture species of fish, the mandarin fish, Siniperca chuatsi, in addition to the previous report of IRF1, IRF2, IRF3 and IRF7 from the fish. These IRFs are constitutively expressed in various organs/tiss …
IRF1-11 with two IRF4, IRF4a and IRF4b have been characterised in an aquaculture species of fish, the mandarin fish, Siniperca chuatsi, in a …
The Third Intron of IRF8 Is a Cell-Type-Specific Chromatin Priming Element during Mouse Embryonal Stem Cell Differentiation.
Khateb M, Azriel A, Levi BZ. Khateb M, et al. J Mol Biol. 2019 Jan 18;431(2):210-222. doi: 10.1016/j.jmb.2018.11.022. Epub 2018 Nov 29. J Mol Biol. 2019. PMID: 30502383
Furthermore, we showed that this intron alone is sufficient to promote repressed chromatin a cell-type-specific manner. Here we demonstrate the effect of the IRF8 third intron on chromatin conformation during murine embryonal stem cell differentiation. ...It acts as …
Furthermore, we showed that this intron alone is sufficient to promote repressed chromatin a cell-type-specific manner. Here we demonstrate …
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.
Yoshimi R, Chang TH, Wang H, Atsumi T, Morse HC 3rd, Ozato K. Yoshimi R, et al. J Immunol. 2009 Jun 15;182(12):7527-38. doi: 10.4049/jimmunol.0804121. J Immunol. 2009. PMID: 19494276 Free PMC article.
The tripartite motif (TRIM) family member, TRIM21, is an E3 ubiquitin ligase for IFN regulatory factor (IRF)3 and IRF8 that functions in both innate and acquired immunity. It is also an autoantigen known as Ro52/SS-A. ...EGFP expression analyses showed that Trim21 was wide …
The tripartite motif (TRIM) family member, TRIM21, is an E3 ubiquitin ligase for IFN regulatory factor (IRF)3 and IRF8 that functions …